FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly.

• Main Authors: Audrey Romano (Author), Xunya Hou (Author), Mathieu Sertorio (Author), Hélia Dessein (Author), Sandrine Cabantous (Author), Pablo Oliveira (Author), Jun Li (Author), Sandrine Oyegue (Author), Violaine Arnaud (Author), Xinsong Luo (Author), Martine Daujat-Chavanieu (Author), Odette Mariani (Author), Xavier Sastre (Author), Anne-Marie Dombey (Author), Hongbin He (Author), Yuesheng Li (Author), Alain Dessein (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) and splenomegaly (SplM). FOXP3+ Tregs could regulate inflammation, but it is unclear where these cells are produced and what roles they play in human schistosomiasis. We investigated blood...