Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study

• Main Authors: Xianxian Liu (Author), Hua Lai (Author), Siming Xin (Author), Zengming Li (Author), Xiaoming Zeng (Author), Liju Nie (Author), Zhengyi Liang (Author), Meiling Wu (Author), Jiusheng Zheng (Author), Yang Zou (Author)
• Format: Book
• Published: BMC, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) can cause premature delivery and stillbirth. Previous studies have reported that mutations in ABC transporter genes strongly influence the transport of bile salts. However, to date, their effects are still largely elusive. Methods A who...