ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2

• Main Authors: Andreas Mæchel Fritzen (Author), Joan Domingo-Espín (Author), Anne-Marie Lundsgaard (Author), Maximilian Kleinert (Author), Ida Israelsen (Author), Christian S. Carl (Author), Trine S. Nicolaisen (Author), Rasmus Kjøbsted (Author), Jacob F. Jeppesen (Author), Jørgen F.P. Wojtaszewski (Author), Jens O. Lagerstedt (Author), Bente Kiens (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, ApoA-1 failed to increase glucose uptake when infect...