Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

• Main Authors: Karen Alejandra Méndez-Lara (Author), Nicole Letelier (Author), Núria Farré (Author), Elena M. G. Diarte-Añazco (Author), Núria Nieto-Nicolau (Author), Elisabeth Rodríguez-Millán (Author), David Santos (Author), Victor Pallarès (Author), Joan Carles Escolà-Gil (Author), Tania Vázquez del Olmo (Author), Enrique Lerma (Author), Mercedes Camacho (Author), Ricardo P Casaroli-Marano (Author), Annabel F. Valledor (Author), Francisco Blanco-Vaca (Author), Josep Julve (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic atherosclerosis was significantly reduced (NAM low dose...