Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

• 主要な著者: Shufang Liu (著者), Ashwni Verma (著者), Hubert Kettenberger (著者), Wolfgang F. Richter (著者), Dhaval K. Shah (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A growing body of evidence supports the important role of molecular charge on antibody pharmacokinetics (PK), yet a quantitative description of the effect of charge on systemic and tissue disposition of antibodies is still lacking. Consequently, we have systematically engineered complementarity-dete...