Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest

• Main Authors: Bingjie Han (Author), Yuanyuan Sun (Author), Xiaofen Zhang (Author), Ping Yue (Author), Meiling Tian (Author), Dan Yan (Author), Fanxiang Yin (Author), Bo Qin (Author), Yi Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The occurrence of cisplatin resistance is still the main factor limiting the therapeutic effect of non-small cell lung cancer (NSCLC). It is urgent to elucidate the resistance mechanism and develop novel treatment strategies. Targeted metabolomics was first performed to detect amino acids' cont...