Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest

• প্রধান লেখক: Bingjie Han (লেখক), Yuanyuan Sun (লেখক), Xiaofen Zhang (লেখক), Ping Yue (লেখক), Meiling Tian (লেখক), Dan Yan (লেখক), Fanxiang Yin (লেখক), Bo Qin (লেখক), Yi Zhao (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The occurrence of cisplatin resistance is still the main factor limiting the therapeutic effect of non-small cell lung cancer (NSCLC). It is urgent to elucidate the resistance mechanism and develop novel treatment strategies. Targeted metabolomics was first performed to detect amino acids' cont...