Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

• Main Authors: Jennifer E. Cropley (Author), Sally A. Eaton (Author), Alastair Aiken (Author), Paul E. Young (Author), Eleni Giannoulatou (Author), Joshua W.K. Ho (Author), Michael E. Buckland (Author), Simon P. Keam (Author), Gyorgy Hutvagner (Author), David T. Humphreys (Author), Katherine G. Langley (Author), Darren C. Henstridge (Author), David I.K. Martin (Author), Mark A. Febbraio (Author), Catherine M. Suter (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Parental obesity can induce metabolic phenotypes in offspring independent of the inherited DNA sequence. Here we asked whether such non-genetic acquired metabolic traits can be passed on to a second generation that has never been exposed to obesity, even as germ cells. Methods: We examine...