Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

• 主要な著者: Jean Claude Alvarez (著者), Benjamin Davido (著者), Pierre Moine (著者), Isabelle Etting (著者), Djillali Annane (著者), Islam Amine Larabi (著者), Nicolas Simon (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD)...