Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD)...

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Main Authors: Jean Claude Alvarez (Author), Benjamin Davido (Author), Pierre Moine (Author), Isabelle Etting (Author), Djillali Annane (Author), Islam Amine Larabi (Author), Nicolas Simon (Author)
Format: Book
Published: MDPI AG, 2022-02-01T00:00:00Z.
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