In vitro to clinical translation of combinatorial effects of doxorubicin and dexrazoxane in breast cancer: a mechanism-based pharmacokinetic/pharmacodynamic modeling approach

• Автори: Hardik Mody (Автор), Tanaya R. Vaidya (Автор), Jovin Lezeau (Автор), Kareem Taha (Автор), Sihem Ait-Oudhia (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Dexrazoxane (DEX) is the only drug clinically approved to treat Doxorubicin-induced cardiotoxicity (DIC), however its impact on the anticancer efficacy of DOX is not extensively studied. In this manuscript, a proof-of-concept in vitro study is carried out to quantitatively characterize the anticance...