Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass

• 主要な著者: Christoph P. Hornik (著者), Daniel Gonzalez (著者), Julie Dumond (著者), Huali Wu (著者), Eric M. Graham (著者), Kevin D. Hill (著者), Michael Cohen‐Wolkowiez (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2019-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Methylprednisolone is used in neonates to modulate cardiopulmonary bypass (CPB)-induced inflammation, but optimal dosing and exposure are unknown. We used plasma methylprednisolone and interleukin (IL)‐6 and IL‐10 concentrations from neonates enrolled in a randomized trial comparing one vs. two dose...