Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

• Main Authors: Yazgı Dizdaroglu (Author), Canan Albay (Author), Tayfun Arslan (Author), Abdulilah Ece (Author), Emir A. Turkoglu (Author), Asiye Efe (Author), Murat Senturk (Author), Claudiu T. Supuran (Author), Deniz Ekinci (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, newly synthesised compounds 6, 8, 10 and other compounds (1-5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1-10 showed effective inhibition profiles with KI values in the range of 5.13-16.9 nM for hCA...