Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

• Autores principales: Yazgı Dizdaroglu (Autor), Canan Albay (Autor), Tayfun Arslan (Autor), Abdulilah Ece (Autor), Emir A. Turkoglu (Autor), Asiye Efe (Autor), Murat Senturk (Autor), Claudiu T. Supuran (Autor), Deniz Ekinci (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

In this study, newly synthesised compounds 6, 8, 10 and other compounds (1-5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1-10 showed effective inhibition profiles with KI values in the range of 5.13-16.9 nM for hCA...