A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes.

• Main Authors: Victoria Gillan (Author), Kerry O'Neill (Author), Kirsty Maitland (Author), Francis M Sverdrup (Author), Eileen Devaney (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel drugs are required for the elimination of infections caused by filarial worms, as most commonly used drugs largely target the microfilariae or first stage larvae of these infections. Previous studies, conducted in vitro, have shown that inhibition of Hsp90 kills adult Brugia pahangi. As numero...