Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals
An innovative moderate-intensity resistive exercise-training (RT) program was tested in thirty-five sarcopenic elders (SAR). The subjects were randomized into two groups: SAR training (SAR-RT), n = 20, 73.0 ± 5.5 years, or SAR non-training (SAR-NT), n = 15, 71.7 ± 3.4 years. The tr...
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MDPI AG,
2019-09-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_e77707e76f7f42a09c05fb2fa84923a2 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Alessandra Vezzoli |e author |
| 700 | 1 | 0 | |a Simona Mrakic-Sposta |e author |
| 700 | 1 | 0 | |a Michela Montorsi |e author |
| 700 | 1 | 0 | |a Simone Porcelli |e author |
| 700 | 1 | 0 | |a Paola Vago |e author |
| 700 | 1 | 0 | |a Ferdinando Cereda |e author |
| 700 | 1 | 0 | |a Stefano Longo |e author |
| 700 | 1 | 0 | |a Marcello Maggio |e author |
| 700 | 1 | 0 | |a Marco Narici |e author |
| 245 | 0 | 0 | |a Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals |
| 260 | |b MDPI AG, |c 2019-09-01T00:00:00Z. | ||
| 500 | |a 2076-3921 | ||
| 500 | |a 10.3390/antiox8100431 | ||
| 520 | |a An innovative moderate-intensity resistive exercise-training (RT) program was tested in thirty-five sarcopenic elders (SAR). The subjects were randomized into two groups: SAR training (SAR-RT), n = 20, 73.0 ± 5.5 years, or SAR non-training (SAR-NT), n = 15, 71.7 ± 3.4 years. The training consisted of 12-week progressive RT, thrice/week, at 60% one-repetition maximum (1RM), 3 sets, 14−16 repetitions for both upper and lower limbs. The pre and post intervention measurements included: the skeletal muscle index (SMI%); strength (1RM); stair-climbing power (SCP); muscle thickness (MT) of vastus lateralis (VL) and elbow flexors (EF), VL pennation angle (PA), rectus femoris (RF) anatomical cross-sectional area (ACSA); reactive oxygen species (ROS), total antioxidant capacity (TAC), protein carbonyls (PC), thiobarbituric acid-reactive substances (TBARS), 8-isoprostane (8-iso-PGF2-α), 8-OH-2-deoxyguanosine (8-OH-dG), as markers of oxidative stress/damage (OxS). In SAR-RT, SCP increased by 7.7% (<i>P</i> < 0.01), MT increased by 5.5% for VL, 10.4% for EF and PA increased by 13.4% for VL (<i>P</i> < 0.001 for all). The RF ACSA increased by 14.5% (<i>P</i> < 0.001). 1RM significantly increased by at least 67% for all muscles tested. Notably muscle strength (1RM) positively correlated (<i>P</i> < 0.001) with TAC and negatively with PC (<i>P</i> < 0.001). In conclusion, moderate intensity RT is an effective strategy to increase muscle mass and strength in SAR, while minimizing OxS. | ||
| 546 | |a EN | ||
| 690 | |a resistive training | ||
| 690 | |a muscle mass | ||
| 690 | |a muscle strength | ||
| 690 | |a oxidative stress | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 8, Iss 10, p 431 (2019) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/8/10/431 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e77707e76f7f42a09c05fb2fa84923a2 |z Connect to this object online. |