lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1

• Hlavní autoři: Duan Li (Autor), Xiaoyan Wang (Autor), Yujie Dang (Autor), Xinyue Zhang (Autor), Shidou Zhao (Autor), Gang Lu (Autor), Wai-Yee Chan (Autor), Peter C.K. Leung (Autor), Yingying Qin (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2021-03-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Dysfunction of granulosa cells (GCs) leading to follicle atresia has been extensively studied as a major cause of premature ovarian insufficiency (POI), but the regulatory role of long non-coding RNAs (lncRNAs) in this process is still poorly understood. Here, we show that the lncRNA LINC02690 or GC...