A metabolome-wide Mendelian randomization study prioritizes causal circulating metabolites for reproductive disorders including primary ovarian insufficiency, polycystic ovary syndrome, and abnormal spermatozoa

• Main Authors: Shuang Chen (Author), Shihao Sun (Author), Mingshu Cai (Author), Zhaokai Zhou (Author), Yuan Ma (Author), Zihan Zhou (Author), Fang Wang (Author), Jinhao Liu (Author), Wenyan Song (Author), Yu Liu (Author), Kai Huang (Author), Qingling Yang (Author), Yihong Guo (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Accumulating studies have highlighted the significant role of circulating metabolomics in the etiology of reproductive system disorders. However, the causal effects between genetically determined metabolites (GDMs) and reproductive diseases, including primary ovarian insufficienc...