New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

• Autors principals: Amal Amaghnouje (Autor), Serhii Bohza (Autor), Nathalie Bohdan (Autor), Imane Es-Safi (Autor), Andrii Kyrylchuk (Autor), Sanae Achour (Autor), Hinde El Fatemi (Autor), Dalila Bousta (Autor), Andriy Grafov (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2021-08-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects...