New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

• Main Authors: Amal Amaghnouje (Author), Serhii Bohza (Author), Nathalie Bohdan (Author), Imane Es-Safi (Author), Andrii Kyrylchuk (Author), Sanae Achour (Author), Hinde El Fatemi (Author), Dalila Bousta (Author), Andriy Grafov (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects...