Tryptophan Substitution in CJ-15,208 (<i>cyclo</i>[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference

• Autori principali: Kristen H. Scherrer (Autore), Shainnel O. Eans (Autore), Jessica M. Medina (Autore), Sanjeewa N. Senadheera (Autore), Tanvir Khaliq (Autore), Thomas F. Murray (Autore), Jay P. McLaughlin (Autore), Jane V. Aldrich (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The macrocyclic tetrapeptide CJ-15,208 (<i>cyclo</i>[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated the effects of substitution of...