Tryptophan Substitution in CJ-15,208 (<i>cyclo</i>[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference

The macrocyclic tetrapeptide CJ-15,208 (<i>cyclo</i>[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated the effects of substitution of...

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Asıl Yazarlar: Kristen H. Scherrer (Yazar), Shainnel O. Eans (Yazar), Jessica M. Medina (Yazar), Sanjeewa N. Senadheera (Yazar), Tanvir Khaliq (Yazar), Thomas F. Murray (Yazar), Jay P. McLaughlin (Yazar), Jane V. Aldrich (Yazar)
Materyal Türü: Kitap
Baskı/Yayın Bilgisi: MDPI AG, 2023-08-01T00:00:00Z.
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3rd Floor Main Library

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