Tryptophan Substitution in CJ-15,208 (<i>cyclo</i>[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference
The macrocyclic tetrapeptide CJ-15,208 (<i>cyclo</i>[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated the effects of substitution of...
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MDPI AG,
2023-08-01T00:00:00Z.
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