Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis

• Main Authors: Linke Huang (Author), Weiwei Chen (Author), Linhua Wei (Author), Yuangang Su (Author), Jiamin Liang (Author), Haoyu Lian (Author), Hui Wang (Author), Feng Long (Author), Fan Yang (Author), Shiyao Gao (Author), Zhen Tan (Author), Jiake Xu (Author), Jinmin Zhao (Author), Qian Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wear debris after total joint arthroplasty can attract the recruitment of macrophages, which release pro-inflammatory substances, triggering the activation of osteoclasts, thereby leading to periprosthetic osteolysis (PPOL) and aseptic loosening. However, the development of pharmacological strategie...