Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

• Main Authors: Chester Costales (Author), Jian Lin (Author), Emi Kimoto (Author), Shinji Yamazaki (Author), James R. Gosset (Author), A. David Rodrigues (Author), Sarah Lazzaro (Author), Mark A. West (Author), Michael West (Author), Manthena V. S. Varma (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Quantitative assessment of drug‐drug interactions (DDIs) involving breast cancer resistance protein (BCRP) inhibition is challenged by overlapping substrate/inhibitor specificity. This study used physiologically‐based pharmacokinetic (PBPK) modeling to delineate the effects of inhibitor dru...