Real-Time Positron Emission Tomography Evaluation of Topotecan Brain Kinetics after Ultrasound-Mediated Blood-Brain Barrier Permeability

• Main Authors: Andrei Molotkov (Author), Patrick Carberry (Author), Martin A. Dolan (Author), Simon Joseph (Author), Sidney Idumonyi (Author), Shunichi Oya (Author), John Castrillon (Author), Elisa E. Konofagou (Author), Mikhail Doubrovin (Author), Glenn J. Lesser (Author), Francesca Zanderigo (Author), Akiva Mintz (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most common primary adult brain malignancy with an extremely poor prognosis and a median survival of fewer than two years. A key reason for this high mortality is that the blood-brain barrier (BBB) significantly restricts systemically delivered therapeutics to brain tumors....