ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3β-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion

• Main Authors: Xirui Guo (Author), Haishan Huang (Author), Honglei Jin (Author), Jiheng Xu (Author), Sanjiv Risal (Author), Jingxia Li (Author), Xin Li (Author), Huiying Yan (Author), Xingruo Zeng (Author), Lei Xue (Author), Changyan Chen (Author), Chuanshu Huang (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our most recent studies demonstrate that miR-137 is downregulated in human bladder cancer (BC) tissues, while treatment of human BC cells with isorhapontigenin (ISO) elevates miR-137 abundance. Since ISO showed a strong inhibition of invasive BC formation in the N-butyl-N-(4-hydroxybutyl) nitrosamin...