Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice

• Main Authors: Kun Li (Author), Jianan Zou (Author), Song Li (Author), Jing Guo (Author), Wentao Shi (Author), Bing Wang (Author), Xiaodong Han (Author), Hongwei Zhang (Author), Pin Zhang (Author), Zengmin Miao (Author), Yousheng Li (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Roux-en-Y gastric bypass surgery (RYGB) can achieve long-term remission of type 2 diabetes. However, the specific molecular mechanism through which this occurs has remained largely elusive. Bile acid signaling through the nuclear hormone receptor farnesoid X receptor (FXR) exerts benefici...