Isovalerylspiramycin I inhibits proliferation, migration and invasion of osteosarcoma cells by targeting Topoisomerase 1 and suppressing the ataxia telangiectasia and Rad3‐related/checkpoint kinase 1 pathway

• मुख्य लेखकों: Jinrong Liang (लेखक), Peng Zhang (लेखक), Kunyan He (लेखक), Yawen Zhang (लेखक), Xiaomin Ding (लेखक), Qian Li (लेखक), Wang Zhou (लेखक), Haiyan Hu (लेखक), Jianjun Zhang (लेखक), Yan Zhou (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Purpose Topoisomerase 1 (TOP1) plays a crucial role in various cell cycle processes and its dysregulation can lead to the development of multiple tumours. However, conventional TOP1 inhibitors such as topotecan and irinotecan have poor clinical efficacy in osteosarcoma (OS) patients. This i...