Isovalerylspiramycin I inhibits proliferation, migration and invasion of osteosarcoma cells by targeting Topoisomerase 1 and suppressing the ataxia telangiectasia and Rad3‐related/checkpoint kinase 1 pathway

• Main Authors: Jinrong Liang (Author), Peng Zhang (Author), Kunyan He (Author), Yawen Zhang (Author), Xiaomin Ding (Author), Qian Li (Author), Wang Zhou (Author), Haiyan Hu (Author), Jianjun Zhang (Author), Yan Zhou (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose Topoisomerase 1 (TOP1) plays a crucial role in various cell cycle processes and its dysregulation can lead to the development of multiple tumours. However, conventional TOP1 inhibitors such as topotecan and irinotecan have poor clinical efficacy in osteosarcoma (OS) patients. This i...