Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

• Main Authors: Grace Mugumbate (Author), Vitor Mendes (Author), Michal Blaszczyk (Author), Mohamad Sabbah (Author), George Papadatos (Author), Joel Lelievre (Author), Lluis Ballell (Author), David Barros (Author), Chris Abell (Author), Tom L. Blundell (Author), John P. Overington (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and structure-based chemogenomic approach...