Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression

• Main Authors: Xin Li (Author), Ye Tian (Author), Mei-Juan Tu (Author), Pui Yan Ho (Author), Neelu Batra (Author), Ai-Ming Yu (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-metabolizing enzymes, transporters, and nuclear receptors are essential for the absorption, distribution, metabolism, and excretion (ADME) of drugs and xenobiotics. MicroRNAs participate in the regulation of ADME gene expression via imperfect complementary WatsonCrick base pairings with target...