Using a Vancomycin PBPK Model in Special Populations to Elucidate Case‐Based Clinical PK Observations

• Glavni autori: Chie Emoto (Autor), Trevor N. Johnson (Autor), Brooks T. McPhail (Autor), Alexander A. Vinks (Autor), Tsuyoshi Fukuda (Autor)
• Format: Knjiga
• Izdano: Wiley, 2018-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Simultaneous changes in several physiological factors may contribute to the large pharmacokinetic (PK) variability of vancomycin. This study was designed to systematically characterize the effects of multiple physiological factors to the altered PK of vancomycin observed in special populations. A va...