Neuroprotective Effects of Kangen-karyu on Spatial Memory Impairment in an 8-Arm Radial Maze and Neuronal Death in the Hippocampal CA1 Region Induced by Repeated Cerebral Ischemia in Rats

• Main Authors: Fengling Pu (Author), Kyoko Motohashi (Author), Tomohiro Kaneko (Author), Yurika Tanaka (Author), Naomi Manome (Author), Keiichi Irie (Author), Jirou Takata (Author), Nobuaki Egashira (Author), Ryozo Oishi (Author), Takuya Okamoto (Author), Yasuo Sei (Author), Takako Yokozawa (Author), Kenichi Mishima (Author), Katsunori Iwasaki (Author), Michihiro Fujiwara (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 × 10 min, 1-h interval). A 21-day pre- and postischemic treatment with KGK (10 - 300 mg/kg) and aspirin (5 mg/kg) improved the spatial memory impairment and neuronal death...