The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.

• Main Authors: Rosario Diaz-Gonzalez (Author), F Matthew Kuhlmann (Author), Cristina Galan-Rodriguez (Author), Luciana Madeira da Silva (Author), Manuel Saldivia (Author), Caitlin E Karver (Author), Ana Rodriguez (Author), Stephen M Beverley (Author), Miguel Navarro (Author), Michael P Pollastri (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Target repurposing utilizes knowledge of "druggable" targets obtained in one organism and exploits this information to pursue new potential drug targets in other organisms. Here we describe such studies to evaluate whether inhibitors targeting the kinase domain of the mammalian Target of R...