Chronic Treatment with a Promnesiant GABA-A 𝜶𝟓-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

• Main Authors: J. Braudeau (Author), L. Dauphinot (Author), A. Duchon (Author), A. Loistron (Author), R. H. Dodd (Author), Y. Hérault (Author), B. Delatour (Author), M. C. Potier (Author)
• Format: Book
• Published: Hindawi Limited, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors (α5IA) have promnesiant activity. Interestingly, we have recently shown that α5IA can rescue cognitive deficits in Ts65Dn mice, a Down syndrome...