Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability

• Main Authors: Lipeng Dong (Author), Huimin Qiao (Author), Xiangjian Zhang (Author), Xiaolin Zhang (Author), Chaohui Wang (Author), Lina Wang (Author), Lili Cui (Author), Jingru Zhao (Author), Yinxue Xing (Author), Yanhua Li (Author), Zongjie Liu (Author), Chunhua Zhu (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Parthenolide (PN) has been proved to elicit a wide range of biological activities through its anti-inflammatory action in the treatment of migraine, arthritis, and atherosclerosis....