The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants.

• Main Authors: Flora S Kano (Author), Flávia A Souza-Silva (Author), Leticia M Torres (Author), Barbara A S Lima (Author), Taís N Sousa (Author), Jéssica R S Alves (Author), Roberto S Rocha (Author), Cor J F Fontes (Author), Bruno A M Sanchez (Author), John H Adams (Author), Cristiana F A Brito (Author), Douglas E V Pires (Author), David B Ascher (Author), Ana Maria Sell (Author), Luzia H Carvalho (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). A high proportion of P. vivax-exposed individua...