Application of physiologically‐based pharmacokinetic model approach to predict pharmacokinetics and drug-drug interaction of rivaroxaban: A case study of rivaroxaban and carbamazepine

• Main Authors: Lien Thi Ngo (Author), Sung‐yoon Yang (Author), Sooyoung Shin (Author), Duc Tuan Cao (Author), Hung Van Nguyen (Author), Sangkeun Jung (Author), Jae‐Young Lee (Author), Jong‐Hwa Lee (Author), Hwi‐yeol Yun (Author), Jung‐woo Chae (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Rivaroxaban (RIV; Xarelto; Janssen Pharmaceuticals, Beerse, Belgium) is one of the direct oral anticoagulants. The drug is a strong substrate of cytochrome P450 (CYP) enzymes and efflux transporters. This study aimed to develop a physiologically‐based pharmacokinetic (PBPK) model for RIV. I...