An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production

• Main Authors: Giulia Breveglieri (Author), Nicoletta Bianchi (Author), Lucia Carmela Cosenza (Author), Maria Rita Gamberini (Author), Francesco Chiavilli (Author), Cristina Zuccato (Author), Giulia Montagner (Author), Monica Borgatti (Author), Ilaria Lampronti (Author), Alessia Finotti (Author), Roberto Gambari (Author)
• Format: Book
• Published: BMC, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI, BCL11A and MYB polymorph...