Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

• Main Authors: Zhenyan Hou (Author), Lei Chen (Author), Pingfei Fang (Author), Hualin Cai (Author), Huaibo Tang (Author), Yongbo Peng (Author), Yang Deng (Author), Lingjuan Cao (Author), Huande Li (Author), Bikui Zhang (Author), Miao Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclea...