TGF-β1 Inhibition of ACE2 Mediated by miRNA Uncovers Novel Mechanism of SARS-CoV-2 Pathogenesis

• Main Authors: Ewelina D. Hejenkowska (Author), Nilay Mitash (Author), Joshua E. Donovan (Author), Anvita Chandra (Author), Carol Bertrand (Author), Chiara De Santi (Author), Catherine M. Greene (Author), Fangping Mu (Author), Agnieszka Swiatecka-Urban (Author)
• Format: Book
• Published: Karger Publishers, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for COVID-19, utilizes receptor binding domain (RBD) of spike glycoprotein to interact with angiotensin (Ang)-converting enzyme 2 (ACE2). Altering ACE2 levels may affect entry of SARS-CoV-2 and recovery from COVID-19. Decr...