WXJ-202, a novel Ribociclib derivative, exerts antitumor effects against breast cancer through CDK4/6

• Главные авторы: Jing Ji (Автор), Wenwen Liu (Автор), Yuxin Xu (Автор), Zhou Xu (Автор), Mingxiao Lv (Автор), Jing Feng (Автор), Jinyu Lv (Автор), Xingbei He (Автор), Zhen Zhang (Автор), Mengru Xie (Автор), Aixin Jing (Автор), Xiujun Wang (Автор), Jinming Ma (Автор), Bin Liu (Автор)
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• Опубликовано: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Предметы: article
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Cyclin-dependent kinases 4 and 6 (CDK4/6) are key regulatory proteins in the cell division and proliferative cycle in humans. They are overactive in many malignant tumors, particularly in triple-negative breast cancer (TNBC). Inhibition of CDK4/6 targets can have anti-tumor effects. Here, we designe...