Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung

• Main Authors: Alexander Taschauer (Author), Wolfram Polzer (Author), Fatih Alioglu (Author), Magdalena Billerhart (Author), Simon Decker (Author), Theresa Kittelmann (Author), Emanuela Geppl (Author), Salma Elmenofi (Author), Martin Zehl (Author), Ernst Urban (Author), Haider Sami (Author), Manfred Ogris (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peptide ligands can enhance delivery of nucleic acid-loaded nanoparticles to tumors by promoting their cell binding and internalization. Lung tumor lesions accessible from the alveolar side can be transfected, in principle, using gene vectors delivered as an aerosol. The cell surface marker CD49f (I...