Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

• Main Authors: Joshua C. Zamora (Author), Hudson R. Smith (Author), Elaine M. Jennings (Author), Teresa S. Chavera (Author), Varun Kotipalli (Author), Aleasha Jay (Author), Stephen M. Husbands (Author), Alex Disney (Author), Kelly A. Berg (Author), William P. Clarke (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan®). Although naloxone is very effective and has saved many lives, as a competitive antagonist it has limitations. Due to the short half‐lif...