Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.

• Main Authors: Felipe Jules de Araujo (Author), Luan Diego Oliveira da Silva (Author), Tirza Gabrielle Mesquita (Author), Suzana Kanawati Pinheiro (Author), Wonei de Seixas Vital (Author), Anette Chrusciak-Talhari (Author), Jorge Augusto de Oliveira Guerra (Author), Sinésio Talhari (Author), Rajendranath Ramasawmy (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

INTRODUCTION:The clinical outcome to Leishmania-infection is determined by the individual adaptive immune T helper cell responses and their interactions with parasitized host cells. An early development of a proinflammatory immune response (Th1 response) is necessary for Leishmania-infection resolut...