Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.

• Egile Nagusiak: Felipe Jules de Araujo (Egilea), Luan Diego Oliveira da Silva (Egilea), Tirza Gabrielle Mesquita (Egilea), Suzana Kanawati Pinheiro (Egilea), Wonei de Seixas Vital (Egilea), Anette Chrusciak-Talhari (Egilea), Jorge Augusto de Oliveira Guerra (Egilea), Sinésio Talhari (Egilea), Rajendranath Ramasawmy (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

INTRODUCTION:The clinical outcome to Leishmania-infection is determined by the individual adaptive immune T helper cell responses and their interactions with parasitized host cells. An early development of a proinflammatory immune response (Th1 response) is necessary for Leishmania-infection resolut...