Lipothioureas as Lipids for Gene Transfection: A Review

• Main Authors: Jean Herscovici (Author), Nathalie Mignet (Author), Michel Bessodes (Author), Jeanne Leblond (Author), Isabelle Tranchant (Author), Daniel Scherman (Author), Marie Breton (Author)
• Format: Book
• Published: MDPI AG, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-viral gene therapy requires innovative strategies to achieve higher transfection efficacy. A few years ago, our group proposed bioinspired lipids whoseinteraction with DNA was not based on ionic interactions, but on hydrogen bonds. We thusdeveloped lipids bearing a thiourea head which allowed an...