Lipothioureas as Lipids for Gene Transfection: A Review

• Päätekijät: Jean Herscovici (Tekijä), Nathalie Mignet (Tekijä), Michel Bessodes (Tekijä), Jeanne Leblond (Tekijä), Isabelle Tranchant (Tekijä), Daniel Scherman (Tekijä), Marie Breton (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2011-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Non-viral gene therapy requires innovative strategies to achieve higher transfection efficacy. A few years ago, our group proposed bioinspired lipids whoseinteraction with DNA was not based on ionic interactions, but on hydrogen bonds. We thusdeveloped lipids bearing a thiourea head which allowed an...