Lipothioureas as Lipids for Gene Transfection: A Review

• Auteurs principaux: Jean Herscovici (Auteur), Nathalie Mignet (Auteur), Michel Bessodes (Auteur), Jeanne Leblond (Auteur), Isabelle Tranchant (Auteur), Daniel Scherman (Auteur), Marie Breton (Auteur)
• Format: Livre
• Publié: MDPI AG, 2011-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Non-viral gene therapy requires innovative strategies to achieve higher transfection efficacy. A few years ago, our group proposed bioinspired lipids whoseinteraction with DNA was not based on ionic interactions, but on hydrogen bonds. We thusdeveloped lipids bearing a thiourea head which allowed an...