Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia

• Main Authors: Kunho Chung (Author), Irfan Ullah (Author), Yujong Yi (Author), Eunhwa Kang (Author), Gyeongju Yun (Author), Seoyoun Heo (Author), Minkyung Kim (Author), Seong-Eun Chung (Author), Seongjun Park (Author), Jaeyeoung Lim (Author), Minhyung Lee (Author), Taiyoun Rhim (Author), Sang-Kyung Lee (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemic stroke-induced neuronal cell death leads to the permanent impairment of brain function. The Fas-mediating extrinsic apoptosis pathway and the cytochrome c-mediating intrinsic apoptosis pathway are two major molecular mechanisms contributing to neuronal injury in ischemic stroke. In this stu...