Functions and inhibitors of CHK1 in cancer therapy

• Main Authors: Kailong Jiang (Author), Minjie Deng (Author), Wenjing Du (Author), Tao Liu (Author), Jia Li (Author), Yubo Zhou (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CHK1 plays a crucial role in cancer biology as it modulates cell cycle checkpoint activation and DNA repair. Furthermore, a number of other cellular functions of CHK1 are also gradually discovered. Based on these biological functions, CHK1 has been regarded as a potential target for cancer therapy,...