Experimental Persistent Infection of BALB/c Mice with Small-Colony Variants of Burkholderia pseudomallei Leads to Concurrent Upregulation of PD-1 on T Cells and Skewed Th1 and Th17 Responses.

• Main Authors: Jia-Xiang See (Author), Chandramathi Samudi (Author), Alireza Saeidi (Author), Nivedita Menon (Author), Leang-Chung Choh (Author), Jamuna Vadivelu (Author), Esaki M Shankar (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Burkholderia pseudomallei (B. pseudomallei), the causative agent of melioidosis, is a deadly pathogen endemic across parts of tropical South East Asia and Northern Australia. B. pseudomallei can remain latent within the intracellular compartment of the host cell over prolonged periods of time, and c...