Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin:  In Vitro Comparative Structure-Activity Studies

• Main Authors: Panchanan Maiti (Author), Jayeeta Manna (Author), Joshua Thammathong (Author), Bobbi Evans (Author), Kshatresh Dutta Dubey (Author), Souvik Banerjee (Author), Gary L. Dunbar (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2021-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Despite its potent anti-amyloid properties, the utility of curcumin (Cur) for the treatment of Alzheimer's disease (AD) is limited due to its low bioavailability. Tetrahydrocurcumin (THC), a more stable metabolite has been found in Cur-treated tissues. We compared the anti-amyloid and neuroprot...