Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin:  In Vitro Comparative Structure-Activity Studies

• Egile Nagusiak: Panchanan Maiti (Egilea), Jayeeta Manna (Egilea), Joshua Thammathong (Egilea), Bobbi Evans (Egilea), Kshatresh Dutta Dubey (Egilea), Souvik Banerjee (Egilea), Gary L. Dunbar (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Despite its potent anti-amyloid properties, the utility of curcumin (Cur) for the treatment of Alzheimer's disease (AD) is limited due to its low bioavailability. Tetrahydrocurcumin (THC), a more stable metabolite has been found in Cur-treated tissues. We compared the anti-amyloid and neuroprot...