Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries

• Main Authors: Ayman Geddawy (Author), Takashi Shimosato (Author), Masashi Tawa (Author), Takeshi Imamura (Author), Tomio Okamura (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We compared mechanical responses to uridine-5'triphosphate (UTP) and 2-(methylthio)adenosine-5'diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP induced endothelium-dependent relaxation th...