The prognostic impact of O 6- methylguanine DNA methyltransferase and epidermal growth factor receptor expressions on primary gliosarcoma: A clinicopathologic and immunohistochemical study of seven cases at a single institution

• Auteurs principaux: Jui-Wei Lin (Auteur), You-Ting Wu (Auteur), I-Wei Chang (Auteur)
• Format: Livre
• Publié: Wolters Kluwer Medknow Publications, 2011-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Context: Gliosarcoma is an uncommon variant of glioblastoma characterized by a biphasic tissue pattern of glial and mesenchymal differentiation. O 6- methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that removes mutagenic and cytotoxic adducts from O 6 -guanine in DNA. Lack of MGMT...