Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lamblia.

• Main Authors: Kelly M Hennessey (Author), Tess R Smith (Author), Jennifer W Xu (Author), Germain C M Alas (Author), Kayode K Ojo (Author), Ethan A Merritt (Author), Alexander R Paredez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Giardiasis is widely acknowledged to be a neglected disease in need of new therapeutics to address toxicity and resistance issues associated with the limited available treatment options. We examined seven protein kinases in the Giardia lamblia genome that are predicted to share an unusual structural...