Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS

• Main Authors: Laurence Whitty-Léveillé (Author), Zachary L. VanAernum (Author), Jorge Alexander Pavon (Author), Christa Murphy (Author), Katie Neal (Author), William Forest (Author), Xinliu Gao (Author), Wendy Zhong (Author), Douglas D. Richardson (Author), Hillary A. Schuessler (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTTransition metals can be introduced in therapeutic protein drugs at various steps of the manufacturing process (e.g. manufacturing raw materials, formulation, storage), and can cause a variety of modifications on the protein. These modifications can potentially influence the efficacy, safety...