The Role of Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis

• Үндсэн зохиолчид: Zaiwei Song (Зохиогч), Yang Hu (Зохиогч), Shuang Liu (Зохиогч), Dan Jiang (Зохиогч), Zhanmiao Yi (Зохиогч), Mason M. Benjamin (Зохиогч), Rongsheng Zhao (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: High-dose methotrexate (HDMTX) is a mainstay therapeutic agent for the treatment of diverse hematological malignancies, and it plays a significant role in interindividual variability regarding the pharmacokinetics and toxicity. The genetic association of HDMTX has been widely investigated...