Genome-wide pan-GPCR cell libraries accelerate drug discovery

• Main Authors: Hanting Yang (Author), Yongfu Wang (Author), Wei Liu (Author), Taiping He (Author), Jiayu Liao (Author), Zhongzhi Qian (Author), Jinghao Zhao (Author), Zhaotong Cong (Author), Dan Sun (Author), Zhixiang Liu (Author), Can Wang (Author), Lingping Zhu (Author), Shilin Chen (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account for about 40% of FDA-approved drugs, representing the most successful drug targets. However, only approximately 15% of the...